Cost
Vagifem and Yuvafem Cost, Generic and Getting Them Online
Vagifem, Yuvafem and generic estradiol vaginal inserts: what the FDA says each treats, which are generics, and where online vaginal estrogen prices stand.
By Julian Caraulani · Updated November 11, 2026
Vagifem and Yuvafem are the same kind of medicine: small estradiol inserts placed in the vagina to treat dryness and soreness after menopause. Yuvafem is a generic-style version of Vagifem. We found no cash price on either maker's page. The cheapest online vaginal estrogen plan we track is $40 a month (Found), though that plan is a cream, not an insert.
Price checked Nov 7 · Cancel anytime · Medication included · No email needed
Facts here come from FDA labels and the FDA drug database, read on 11 November 2026. We print no pharmacy prices because we could not source one from a primary page.
What Vagifem and Yuvafem are
Both contain estradiol, an estrogen. Both are tablets or inserts used inside the vagina, so most of the medicine stays local. The Vagifem label says it is "an estrogen indicated for the treatment of atrophic vaginitis due to menopause" (DailyMed label). Atrophic vaginitis means thin, dry, sore vaginal tissue.
The FDA record shows Vagifem is made by Novo Nordisk under application NDA020908, first approved on 26 March 1999 (openFDA Drugs@FDA data). Yuvafem is made by Amneal under a separate generic application, ANDA205256 (openFDA label data).
Is there a generic Vagifem?
Yes. The FDA's database lists estradiol vaginal tablets from Teva (approved 21 July 2017) and Glenmark (approved 14 September 2018). Both are rated "AB," meaning the FDA treats them as interchangeable with Vagifem (openFDA Drugs@FDA data).
Yuvafem is also a generic approved through that same route. So a pharmacist can often fill a prescription for "estradiol vaginal inserts" with a generic. Ask your pharmacist which maker they stock.
Price checked Nov 7 · Cancel anytime · Medication included · No email needed
Vagifem vs Yuvafem vs estradiol inserts
The names differ, but the label for each describes an estradiol product for the same menopause condition. Here is how they line up.
| Name | Maker on the FDA record | Type |
|---|---|---|
| Vagifem | Novo Nordisk | Brand |
| Yuvafem | Amneal | Generic with a brand-style name |
| Estradiol vaginal tablets | Teva, Glenmark | Generic |
We do not rank them. Which one your pharmacy fills depends on stock and on what your prescriber writes.
What do they cost?
Neither maker publishes a cash price on the pages we read. Pharmacies set their own prices, and insurance changes what you pay. Ask two or three pharmacies for a cash quote for the generic and the brand. A discount card is not insurance, and it usually cannot be combined with an insurance claim.
Our estradiol cost guide explains cash routes in plain steps. On Medicare, see Medicare HRT coverage.
Getting vaginal estrogen online
Some online programs on our site sell vaginal estrogen after a clinician review. Most list a cream, not an insert. Whether a program prescribes an insert is the clinician's call, and we cannot say any program will. See the vaginal estradiol price page and the best vaginal estrogen programs for current plan facts and ratings.
If you want to compare the cream with inserts, our estradiol vaginal cream guide covers it. For the full list of options, including moisturizers, see vaginal atrophy treatment options.
Where inserts fit among vaginal options
The Menopause Society says "Low-dose vaginal ET preparations include creams, tablets, rings, and a softgel vaginal insert" (The Menopause Society). Here "ET" means estrogen therapy. Inserts are one of several forms, so ask your clinician which suits you.
Safety label, in plain words
Estrogen labels carry a boxed warning, the FDA's strongest type. The Vagifem warning title reads "ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, PROBABLE DEMENTIA, and BREAST CANCER" (DailyMed label). The endometrium is the lining of the uterus. Your prescriber weighs these points with you.
FAQ
Vagifem and Yuvafem cost: how much do they cost?
We found no cash price on the makers' pages, and pharmacies set their own. The reliable number is a quote from your pharmacy for the generic and the brand. Our live price table shows what online programs charge for vaginal estrogen as a cream.
What is Yuvafem?
Yuvafem is an estradiol vaginal insert made by Amneal under a generic application. Its label says it is indicated for "the treatment of atrophic vaginitis due to menopause." It matches Vagifem's use, with a different name and maker.
What is the Vagifem generic?
The FDA lists estradiol vaginal tablets from Teva and Glenmark, rated "AB," meaning interchangeable with Vagifem. Yuvafem is another generic-route product. Ask your pharmacist which version they stock and what each costs.
Are estradiol vaginal inserts the same as vaginal tablets?
Yes in practice. The FDA lists these products as "tablet" for the vagina, and brands call them inserts. Both mean a small estradiol tablet placed in the vagina. The wording differs, not the product type.
Can I get Vagifem or Yuvafem online?
You need a prescription, and a clinician decides what to prescribe. Some programs on our site prescribe vaginal estrogen, mostly as a cream. We cannot say any will prescribe inserts. Check each program's own page before you sign up.
Do these inserts help with hot flashes?
The label lists only vaginal tissue changes after menopause. They are meant for local symptoms such as dryness and soreness. For hot flashes, ask your clinician about other options.
For what whole programs charge, see what online HRT costs and our best HRT programs.
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