Estradiol Shortage Tracker
As of November 6, 2026, FDA's Drug Shortages Database has no estradiol entry, and its latest statement says patches "remain available" while patients report trouble finding their usual ones. At Mark Cuban Cost Plus Drug Company, 6 of 11 patch listings show "Temporarily Out of Stock", 2 say the lowest-cost version is unavailable, and 3 show no stock notice, from $39.18 a pack.
By Julian Caraulani, reviewed by Dr. A. Goher, MBBS · sources last read · not medical advice
Official status
| Source | What it shows | We read it |
|---|---|---|
| FDA: update on estradiol transdermal patch availabilityContent current as of 3 Sep 2026 | "Although availability of certain products or brands may vary by pharmacy or location, estradiol transdermal patches remain available." | November 6, 2026 |
| FDA Drug Shortages DatabasePage lists updates through 4 Nov 2026 | No estradiol entry in its current and resolved list. The openFDA drug shortages feed, updated 5 Nov 2026, answers "No matches found!" for estradiol, in any field. | November 6, 2026 |
| ASHP drug shortages list | We could not read this list: it refuses automated requests. We make no claim about it. | Not read |
Progesterone vaginal gel is the one nearby entry the openFDA feed returned for progesterone: status "To Be Discontinued", updated 03/27/2026. It is not an estradiol product.
Stock notes and cash prices by form
These are one public seller's listings, cheapest first, read on its own pages. We earn nothing from them. Strength appears only because each one is sold and priced separately. A cash pharmacy needs a prescription from your own clinician. The seller says: "Your final cost will include shipping and taxes, which vary by location."
Patches
| Listing | Price | Seller's stock note | Source |
|---|---|---|---|
| Weekly patch, 0.075 mg, 4 patches (generic for Climara) | $34.90 | "Temporarily Out of Stock" | read 2026-11-06 |
| Weekly patch, 0.1 mg, 4 patches (generic for Climara) | $34.90 | "Temporarily Out of Stock" | read 2026-11-06 |
| Weekly patch, 0.05 mg, 4 patches (generic for Climara) | $35.12 | "Temporarily Out of Stock" | read 2026-11-06 |
| Weekly patch, 0.025 mg, 4 patches (generic for Climara) | $36.02 | "Temporarily Out of Stock" | read 2026-11-06 |
| Once-weekly patch, 0.06 mg, 4 patches | $36.05 | "Temporarily Out of Stock" | read 2026-11-06 |
| Twice-weekly patch, 0.025 mg, 8 patches | $39.18 | No stock notice on the page | read 2026-11-06 |
| Twice-weekly patch, 0.0375 mg, 8 patches | $39.18 | No stock notice on the page | read 2026-11-06 |
| Twice-weekly patch, 0.05 mg, 8 patches | $39.18 | No stock notice on the page | read 2026-11-06 |
| Weekly patch, 0.0375 mg, 4 patches (generic for Climara) | $42.95 | "Temporarily Out of Stock" | read 2026-11-06 |
| Lyllana twice-weekly patch, 0.0375 mg/24hr, 8 patches | $94.61 | "The lowest-cost version of this medication is temporarily unavailable. An alternative product is currently being offered. We expect the lower-priced option to return around November 15, 2026." | read 2026-11-06 |
| Lyllana twice-weekly patch, 0.1 mg/24hr, 8 patches | $94.61 | "The lowest-cost version of this medication is temporarily unavailable. An alternative product is currently being offered. We expect the lower-priced option to return around November 10, 2026." | read 2026-11-06 |
Gel
| Listing | Price | Seller's stock note | Source |
|---|---|---|---|
| Gel, 1.25 mg/1.25 g (generic for Divigel) | $20.67 | "Temporarily Out of Stock" | read 2026-11-06 |
| Gel, 0.5 mg/0.5 g, 30 packets (generic for Divigel) | $22.17 | "Temporarily Out of Stock" | read 2026-11-06 |
| Gel, 0.25 mg/0.25 g, 30 packets (generic for Divigel) | $23.43 | "Temporarily Out of Stock" | read 2026-11-06 |
| Gel, 1 mg/g, 30 packets (generic for Divigel) | $26.85 | "Temporarily Out of Stock" | read 2026-11-06 |
| Gel, 0.75 mg/0.75 g, 30 packets (generic for Divigel) | $28 | "Temporarily Out of Stock" | read 2026-11-06 |
Oral tablets
| Listing | Price | Seller's stock note | Source |
|---|---|---|---|
| Oral tablet, 0.5 mg, 30 count supply | $6.04 | No stock notice on the page | read 2026-11-06 |
| Oral tablet, 1 mg, 30 count supply | $6.76 | No stock notice on the page | read 2026-11-06 |
Vaginal cream and inserts
| Listing | Price | Seller's stock note | Source |
|---|---|---|---|
| Vaginal cream 0.01%, one 42.5 g tube | $13.21 | No stock notice on the page | read 2026-11-06 |
| Vaginal tablet 10 mcg, 30 count supply | $87.42 | No stock notice on the page | read 2026-11-06 |
Online programs that prescribe estradiol
Each program's lowest published all-in estradiol plan, lowest price first, computed from our price data. The form varies by plan. We hold no stock statement for these programs, so ask before paying.
| Program and plan | Per month | Checked | Link |
|---|---|---|---|
| WinonaEstrogen tablets (estradiol) | $54 | 2026-11-05 | Visit Winona (paid link) |
| Gala HealthMenopause program | $69 | 2026-11-05 | Visit Gala Health (paid link) |
| FoundEstrogen or progesterone alone, without insurance | $89 | 2026-11-05 | Visit Found (paid link) |
| Hone HealthWomen's Premium + estradiol gel | $213 | 2026-11-02 | Not a partner |
History
- FDA database and openFDA feed re-read: still no estradiol entry. FDA's 3 Sep 2026 statement is still the latest. Cost Plus Drugs listings read for the first time on this page. FDA Drug Shortages Database
- Our earlier read of the FDA database, recorded in our patch guide: no estradiol patch entry in its current, resolved or discontinued lists. FDA Drug Shortages Database
- San Mateo County Supervisor Jackie Speier wrote to Members of Congress urging them to demand that FDA "declare an official shortage or similar status of Estradiol Transdermal Patches". This is a request, not an FDA finding. San Mateo County
- FDA: "The FDA is aware of reports of patients having difficulty readily accessing their usual estradiol transdermal patches due to increased demand and is working with all six manufacturers to increase supply." It adds that "Over the last year, the supply of FDA-approved estradiol transdermal patches has nearly doubled." FDA: update on estradiol transdermal patch availability
- FDA says demand rose after this action: "Demand for these products increased following the November 2025 action by the FDA to request that manufacturers make changes to the labeling to remove boxed warnings". FDA: update on estradiol transdermal patch availability
Questions
Is there an official estradiol patch shortage?
Not on FDA's records as of November 6, 2026. Its Drug Shortages Database has no estradiol entry. FDA's latest statement, from 3 September 2026, says patients report difficulty finding their usual patches and that patches remain available.
Why do some sellers show patches out of stock?
FDA says availability of certain products or brands may vary by pharmacy or location, and ties the difficulty to increased demand. A stock note on this page is one seller's page on the date shown. It says nothing about your local pharmacy.
What should I do if I cannot find my patch?
FDA says to contact your pharmacist, talk with your healthcare provider and check back with your pharmacy. It also says: do not stop or change your medication without talking with your healthcare provider.
Do online programs have patches in stock?
We do not publish program stock claims unless a program states them on a page we read. Ask the program before paying. The prices below are read from each program's own page.
How to cite this page
HRT Watchdog, "Estradiol Shortage Tracker", sources last read November 6, 2026, https://hrtwatchdog.com/data/estradiol-shortage-tracker. Free to reuse under CC BY 4.0 with attribution.
Some programs pay us a commission when a reader signs up through a link marked paid; that never changes the order, which is by price here. How we make money. More: what to do if you cannot find your patch, estrogen prices, open data. HRT Watchdog is for information only and is not medical advice. Hormone therapy has benefits and risks; talk to a licensed clinician about whether it is right for you.