Estradiol Patch Price: Every Listing We Could Read
As of November 6, 2026, estradiol patches cost from $39.18 for a pack at Cost Plus Drugs on a listing with no stock notice, plus shipping and your own prescription, and from $149 a month at Winona (Estrogen patch), an online program.
By Julian Caraulani, reviewed by Dr. A. Goher, MBBS · public prices read · links marked paid may earn us a commission; they never change the order
$149 a month · Estrogen patch · checked 2026-11-05
An estradiol patch delivers estradiol through the skin and is changed once or twice a week, depending on the product. Your clinician chooses the product and strength. This page lists what each listed strength and program costs, never how to use it.
Online programs
Every published plan a reader can pay as shown, lowest first. Each price was read on the program's own page.
| Program and plan | Per month | What it is | Checked | Link |
|---|---|---|---|---|
| WinonaEstrogen patch | $149auto-refill | FDA-approved | 2026-11-05 | Visit (paid link) |
Public cash listings at Mark Cuban Cost Plus Drug Company
Cheapest first, as published on the seller's pages. 8 of 11 show a stock notice. We earn nothing from these. A pack price is not a monthly price. The seller says: "Your final cost will include shipping and taxes, which vary by location."
| Listing | Price | Seller's stock note | Source |
|---|---|---|---|
| Weekly patch, 0.075 mg, 4 patches (generic for Climara) | $34.90 | "Temporarily Out of Stock" | read 2026-11-06 |
| Weekly patch, 0.1 mg, 4 patches (generic for Climara) | $34.90 | "Temporarily Out of Stock" | read 2026-11-06 |
| Weekly patch, 0.05 mg, 4 patches (generic for Climara) | $35.12 | "Temporarily Out of Stock" | read 2026-11-06 |
| Weekly patch, 0.025 mg, 4 patches (generic for Climara) | $36.02 | "Temporarily Out of Stock" | read 2026-11-06 |
| Once-weekly patch, 0.06 mg, 4 patches | $36.05 | "Temporarily Out of Stock" | read 2026-11-06 |
| Twice-weekly patch, 0.025 mg, 8 patches | $39.18 | No stock notice on the page | read 2026-11-06 |
| Twice-weekly patch, 0.0375 mg, 8 patches | $39.18 | No stock notice on the page | read 2026-11-06 |
| Twice-weekly patch, 0.05 mg, 8 patches | $39.18 | No stock notice on the page | read 2026-11-06 |
| Weekly patch, 0.0375 mg, 4 patches (generic for Climara) | $42.95 | "Temporarily Out of Stock" | read 2026-11-06 |
| Lyllana twice-weekly patch, 0.0375 mg/24hr, 8 patches | $94.61 | "The lowest-cost version of this medication is temporarily unavailable. An alternative product is currently being offered. We expect the lower-priced option to return around November 15, 2026." | read 2026-11-06 |
| Lyllana twice-weekly patch, 0.1 mg/24hr, 8 patches | $94.61 | "The lowest-cost version of this medication is temporarily unavailable. An alternative product is currently being offered. We expect the lower-priced option to return around November 10, 2026." | read 2026-11-06 |
Questions
What is the price of estradiol patches?
As of November 6, 2026, estradiol patches cost from $39.18 for a pack at Cost Plus Drugs on a listing with no stock notice, plus shipping and your own prescription, and from $149 a month at Winona (Estrogen patch), an online program.
Why is a cash pharmacy price lower than a program's price?
Mark Cuban Cost Plus Drug Company sells the drug alone and needs a prescription from your own clinician. The seller says: "Your final cost will include shipping and taxes, which vary by location." A program's price usually includes the clinician visit and delivery, as each row states.
Can I switch patch brands if mine is out of stock?
FDA says your pharmacist may be able to help locate another available FDA-approved estradiol patch that can be substituted when appropriate, and that you should not stop or change your medication without talking with your healthcare provider.
Do these prices tell me which strength to use?
No. A strength is listed only because each one is sold and priced separately. Your clinician decides what is right for you.
HRT Watchdog is for information only and is not medical advice. Hormone therapy has benefits and risks; talk to a licensed clinician about whether it is right for you. We list prices only, never doses.